P2Y(1)R-initiated, IP(3)R-dependent stimulation of astrocyte mitochondrial metabolism reduces and partially reverses ischemic neuronal damage in mouse

Glia-based neuroprotection strategies are emerging as promising new avenues to treat brain damage. We previously reported that activation of the glial-specific purinergic receptor, P2Y(1)R, reduces both astrocyte swelling and brain infarcts in a photothrombotic mouse model of stroke. These restorati...

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Hlavní autoři: Zheng, Wei, Talley Watts, Lora, Holstein, Deborah M, Wewer, Jimmy, Lechleiter, James D
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618399/
https://ncbi.nlm.nih.gov/pubmed/23321785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.214
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