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DIDS (4,4-Diisothiocyanatostilbenedisulphonic Acid) Induces Apoptotic Cell Death in a Hippocampal Neuronal Cell Line and Is Not Neuroprotective against Ischemic Stress

DIDS is a commonly used anion channel antagonist that is putatively cytoprotective against ischemic insult. However, recent reports indicate potentially deleterious secondary effects of DIDS. To assess the impact of DIDS on cellular viability comprehensively we examined neuronal morphology and funct...

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Detalhes bibliográficos
Main Authors: Pamenter, Matthew E., Perkins, Guy A., Gu, Xiang Q., Ellisman, Mark H., Haddad, Gabriel G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618322/
https://ncbi.nlm.nih.gov/pubmed/23577164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060804
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