A HIGH COVERAGE GENOME SEQUENCE FROM AN ARCHAIC DENISOVAN INDIVIDUAL

We present a DNA library preparation method that has allowed us to reconstruct a high coverage (30X) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archai...

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Main Authors: Meyer, Matthias, Kircher, Martin, Gansauge, Marie-Theres, Li, Heng, Racimo, Fernando, Mallick, Swapan, Schraiber, Joshua G., Jay, Flora, Prüfer, Kay, de Filippo, Cesare, Sudmant, Peter H., Alkan, Can, Fu, Qiaomei, Do, Ron, Rohland, Nadin, Tandon, Arti, Siebauer, Michael, Green, Richard E., Bryc, Katarzyna, Briggs, Adrian W., Stenzel, Udo, Dabney, Jesse, Shendure, Jay, Kitzman, Jacob, Hammer, Michael F., Shunkov, Michael V., Derevianko, Anatoli P., Patterson, Nick, Andrés, Aida M., Eichler, Evan E., Slatkin, Montgomery, Reich, David, Kelso, Janet, Pääbo, Svante
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617501/
https://ncbi.nlm.nih.gov/pubmed/22936568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1224344
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