Insulin Signaling in Type 2 Diabetes: EXPERIMENTAL AND MODELING ANALYSES REVEAL MECHANISMS OF INSULIN RESISTANCE IN HUMAN ADIPOCYTES

Type 2 diabetes originates in an expanding adipose tissue that for unknown reasons becomes insulin resistant. Insulin resistance reflects impairments in insulin signaling, but mechanisms involved are unclear because current research is fragmented. We report a systems level mechanistic understanding...

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Bibliografiska uppgifter
Huvudupphovsmän: Brännmark, Cecilia, Nyman, Elin, Fagerholm, Siri, Bergenholm, Linnéa, Ekstrand, Eva-Maria, Cedersund, Gunnar, Strålfors, Peter
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Molecular Bases of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617287/
https://ncbi.nlm.nih.gov/pubmed/23400783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.432062
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