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Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

The cannabinoid receptor 1 (CB1) is a G protein-coupled receptor primarily expressed in brain tissue that has been implicated in several disease states. CB1 allosteric compounds, such as ORG27569, offer enormous potential as drugs over orthosteric ligands, but their mechanistic, structural, and down...

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Bibliografiske detaljer
Main Authors: Ahn, Kwang H., Mahmoud, Mariam M., Shim, Joong-Youn, Kendall, Debra A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617280/
https://ncbi.nlm.nih.gov/pubmed/23449980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438804
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