Intrinsic Epigenetic Regulation of the D4Z4 Macrosatellite Repeat in a Transgenic Mouse Model for FSHD

Facioscapulohumeral dystrophy (FSHD) is a progressive muscular dystrophy caused by decreased epigenetic repression of the D4Z4 macrosatellite repeats and ectopic expression of DUX4, a retrogene encoding a germline transcription factor encoded in each repeat. Unaffected individuals generally have mor...

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書誌詳細
主要な著者: Krom, Yvonne D., Thijssen, Peter E., Young, Janet M., den Hamer, Bianca, Balog, Judit, Yao, Zizhen, Maves, Lisa, Snider, Lauren, Knopp, Paul, Zammit, Peter S., Rijkers, Tonnie, van Engelen, Baziel G. M., Padberg, George W., Frants, Rune R., Tawil, Rabi, Tapscott, Stephen J., van der Maarel, Silvère M.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616921/
https://ncbi.nlm.nih.gov/pubmed/23593020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003415
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