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Early Endosomal Abnormalities and Cholinergic Neuron Degeneration in Amyloid-β Protein Precursor Transgenic Mice

Early endosomal changes, a prominent pathology in neurons early in Alzheimer’s disease, also occur in neurons and peripheral tissues in Down syndrome. While in Down syndrome models increased amyloid-β protein precursor (AβPP) expression is known to be a necessary contributor on the trisomic backgrou...

詳細記述

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書誌詳細
主要な著者: Choi, Jennifer H.K., Kaur, Gurjinder, Mazzella, Matthew J., Morales-Corraliza, Jose, Levy, Efrat, Mathews, Paul M.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616896/
https://ncbi.nlm.nih.gov/pubmed/23254640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-122143
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