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Mechanisms and consequences of localized, complex chromosomal rearrangements in cancer and developmental diseases
Next-generation DNA sequencing of human tumors has led to discovery of chromoanagenesis, in which large numbers of complex rearrangements occur at one or a few chromosomal loci in a single catastrophic event. Two mechanisms underlie these rearrangements, both of which can be facilitated by a mitotic...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616639/ https://ncbi.nlm.nih.gov/pubmed/23135524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2988 |
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