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Emerging roles of E2Fs in cancer: an exit from cell cycle control
Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating the RB pathway have been identified in almost every human malignancy. The E2F transcription factors function in cell cycle control and are intimately regulated by RB. Studies of model organisms have revealed conser...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616489/ https://ncbi.nlm.nih.gov/pubmed/19851314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2696 |
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