Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer

LKB1/STK11 is a tumor suppressor and a negative regulator of mammalian target of rapamycin signaling. It is inactivated in 30% of lung cancer cell lines but only 5–15% of primary lung adenocarcinomas. There is evidence that homozygous deletion (HD) of chromosome 19p at the LKB locus contributes to t...

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Autori principali: Gill, RK, Yang, S-H, Meerzaman, D, Mechanic, LE, Bowman, ED, Jeon, H-S, Chowdhuri, S Roy, Shakoori, A, Dracheva, T, Hong, K-M, Fukuoka, J, Zhang, J-H, Harris, CC, Jen, J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616488/
https://ncbi.nlm.nih.gov/pubmed/21532627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.98
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