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EGFR-Targeted Granzyme B Expressed in NK Cells Enhances Natural Cytotoxicity and Mediates Specific Killing of Tumor Cells

Natural killer (NK) cells are highly specialized effectors of the innate immune system that hold promise for adoptive cancer immunotherapy. Their cell killing activity is primarily mediated by the pro-apoptotic serine protease granzyme B (GrB), which enters targets cells with the help of the pore-fo...

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Detalhes bibliográficos
Main Authors: Oberoi, Pranav, Jabulowsky, Robert A., Bähr-Mahmud, Hayat, Wels, Winfried S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616035/
https://ncbi.nlm.nih.gov/pubmed/23573299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061267
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