Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined “Complementary Lethality”

A high mutation rate leading to tumor cell heterogeneity is a driver of malignancy in human cancers. Paradoxically, however, genomic instability can also render tumors vulnerable to therapeutic attack. Thus, targeting DNA repair may induce an intolerable level of DNA damage in tumor cells. BRCA2 med...

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Autors principals: Rytelewski, Mateusz, Ferguson, Peter J, Vareki, Saman Maleki, Figueredo, Rene, Vincent, Mark, Koropatnick, James
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615817/
https://ncbi.nlm.nih.gov/pubmed/23481354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.7
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