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Physiological release of endogenous tau is stimulated by neuronal activity
Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown. We show that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from healthy, mature cortical neurons. Notably, phosphoryla...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
European Molecular Biology Organization
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3615658/ https://ncbi.nlm.nih.gov/pubmed/23412472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.15 |
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