Physiological release of endogenous tau is stimulated by neuronal activity

Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown. We show that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from healthy, mature cortical neurons. Notably, phosphoryla...

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Hlavní autoři: Pooler, Amy M, Phillips, Emma C, Lau, Dawn H W, Noble, Wendy, Hanger, Diane P
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
Témata:
Scientific Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615658/
https://ncbi.nlm.nih.gov/pubmed/23412472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.15
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