Ubiquitin Ligase Cbl-b Is Involved in Icotinib (BPI-2009H)-Induced Apoptosis and G1 Phase Arrest of EGFR Mutation-Positive Non-Small-Cell Lung Cancer

Epidermal growth factor receptor (EGFR) is one of the most promising targets for non-small-cell lung cancer (NSCLC). Icotinib, a highly selective EGFR tyrosine kinase inhibitor (EGFR-TKI), has shown promising clinical efficacy and safety in patients with NSCLC. The exact molecular mechanism of icoti...

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Bibliographic Details
Main Authors: Mu, Xiaodong, Zhang, Ye, Qu, Xiujuan, Hou, Kezuo, Kang, Jian, Hu, Xuejun, Liu, Yunpeng
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615596/
https://ncbi.nlm.nih.gov/pubmed/23586056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/726375
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