The zinc transporter SLC39A8 is a negative feedback regulator of NF-κB through zinc-mediated inhibition of IKK

Activation of the transcription factor NF-κB is essential to innate immune function and requires strict regulation. The micronutrient zinc modulates proper host defense and zinc deficiency is associated with elevated inflammation and worse outcomes in response to bacterial infection and sepsis. Prev...

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Bibliographic Details
Main Authors: Liu, Ming-Jie, Bao, Shengying, Gálvez-Peralta, Marina, Pyle, Charlie J., Rudawsky, Andrew C., Pavlovicz, Ryan E., Killilea, David W., Li, Chenglong, Nebert, Daniel W., Wewers, Mark D., Knoell, Daren L.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615478/
https://ncbi.nlm.nih.gov/pubmed/23403290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.01.009
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