Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening

Heat shock protein 90 (Hsp90), whose inhibitors have shown promising activity in clinical trials, is an attractive anticancer target. In this work, we first explored the significant pharmacophore features needed for Hsp90 inhibitors by generating a 3D-QSAR pharmacophore model. It was then used to vi...

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Detalhes bibliográficos
Main Authors: Jia, JianMin, Xu, XiaoLi, Liu, Fang, Guo, XiaoKe, Zhang, MingYe, Lu, MengChen, Xu, LiLi, Wei, JinLian, Zhu, Jia, Zhang, ShengLie, Zhang, ShengMiao, Sun, HaoPeng, You, QiDong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615092/
https://ncbi.nlm.nih.gov/pubmed/23565147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059315
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