A mutation in the putative Mg(2+)-binding site of Gs alpha prevents its activation by receptors.

The properties of a Gs alpha mutant with an Asn substituted for Ser at position 54, designated mutant 54Asn alpha s, were studied after expression in S49 alpha s-deficient (cyc-) cells. Ser-54 in alpha s is comparable to Ser-17 in Ras, which is involved in binding Mg2+ associated with bound nucleoti...

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Publicado en:	Mol Cell Biol
Autores principales:	Hildebrandt, J D, Day, R, Farnsworth, C L, Feig, L A
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1991
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361450/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1656212/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.10.4830-4838.1991
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