Structure–activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

Recently, we described the first small-molecule inhibitor, (E)-ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate (1), of the PDZ domain of protein interacting with Cα-kinase 1 (PICK1), a potential drug target against brain ischemia, pain and cocaine addiction. Herein, we explore structure–activi...

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Main Authors: Bach, Anders, Stuhr-Hansen, Nicolai, Thorsen, Thor S., Bork, Nicolai, Moreira, Irina S., Frydenvang, Karla, Padrah, Shahrokh, Christensen, S. Brøgger, Madsen, Kenneth L., Weinstein, Harel, Gether, Ulrik, Strømgaard, Kristian
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3614091/
https://ncbi.nlm.nih.gov/pubmed/20668766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0ob00025f
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