Structure–activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

Recently, we described the first small-molecule inhibitor, (E)-ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate (1), of the PDZ domain of protein interacting with Cα-kinase 1 (PICK1), a potential drug target against brain ischemia, pain and cocaine addiction. Herein, we explore structure–activi...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Bach, Anders, Stuhr-Hansen, Nicolai, Thorsen, Thor S., Bork, Nicolai, Moreira, Irina S., Frydenvang, Karla, Padrah, Shahrokh, Christensen, S. Brøgger, Madsen, Kenneth L., Weinstein, Harel, Gether, Ulrik, Strømgaard, Kristian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3614091/
https://ncbi.nlm.nih.gov/pubmed/20668766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0ob00025f
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items