Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: Identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue

The principal role of acetylcholinesterase (AChE) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. The active site of AChE is near the bottom of a long and narrow gorge lined with aromatic residues. It contains a catalytic ‘ani...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Triquigneaux, Mathilde M., Ehrenshaft, Marilyn, Roth, Esther, Silman, Israel, Ashani, Yakov, Mason, Ronald P., Weiner, Lev, Deterding, Leesa J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613852/
https://ncbi.nlm.nih.gov/pubmed/22888904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120992
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