Neurogenin 3(+) cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas

We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to β cells ex vivo. Here we evaluate the role of Ngn3(+) cells in β cell expansion in situ. PDL not only induced doubling of the β cell vol...

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Detaylı Bibliyografya
Asıl Yazarlar: Van de Casteele, M, Leuckx, G, Baeyens, L, Cai, Y, Yuchi, Y, Coppens, V, De Groef, S, Eriksson, M, Svensson, C, Ahlgren, U, Ahnfelt-Rønne, J, Madsen, O D, Waisman, A, Dor, Y, Jensen, J N, Heimberg, H
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2013
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613830/
https://ncbi.nlm.nih.gov/pubmed/23470530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.52
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