Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration

The UPR is activated in the mouse retina expressing misfolded T17M rhodopsin (RHO) during autosomal dominant retinitis pigmentosa (ADRP) progression. Therefore, the goal of this study is to validate the UPR-induced caspase-7 as a new therapeutic target that modulates the UPR, reduces the level of ap...

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Main Authors: Choudhury, S, Bhootada, Y, Gorbatyuk, O, Gorbatyuk, M
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613823/
https://ncbi.nlm.nih.gov/pubmed/23470535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.34
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