FANCJ couples replication past natural fork barriers with maintenance of chromatin structure

Defective DNA repair causes Fanconi anemia (FA), a rare childhood cancer–predisposing syndrome. At least 15 genes are known to be mutated in FA; however, their role in DNA repair remains unclear. Here, we show that the FANCJ helicase promotes DNA replication in trans by counteracting fork stalling o...

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Bibliografske podrobnosti
Main Authors: Schwab, Rebekka A., Nieminuszczy, Jadwiga, Shin-ya, Kazuo, Niedzwiedz, Wojciech
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2013
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613694/
https://ncbi.nlm.nih.gov/pubmed/23530069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201208009
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