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FANCJ couples replication past natural fork barriers with maintenance of chromatin structure
Defective DNA repair causes Fanconi anemia (FA), a rare childhood cancer–predisposing syndrome. At least 15 genes are known to be mutated in FA; however, their role in DNA repair remains unclear. Here, we show that the FANCJ helicase promotes DNA replication in trans by counteracting fork stalling o...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3613694/ https://ncbi.nlm.nih.gov/pubmed/23530069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201208009 |
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