Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells.

Gene targeting has been used to direct mutations into specific chromosomal loci in murine embryonic stem (ES) cells. The altered locus can be studied in vivo with chimeras and, if the mutated cells contribute to the germ line, in their offspring. Although homologous recombination is the basis for th...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Hasty, P, Rivera-Pérez, J, Chang, C, Bradley, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1875936/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.9.4509-4517.1991
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