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Mechanism and Specificity of an Acyltransferase Domain from a Modular Polyketide Synthase
Acyltransferase (AT) domains of modular polyketide synthases exercise tight control over the choice of α-carboxyacyl-CoA substrates, but the mechanistic basis for this specificity is unknown. We show that whereas the specificity for the electrophilic malonyl or methylmalonyl component is primarily e...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3612939/ https://ncbi.nlm.nih.gov/pubmed/23452124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400185v |
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