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Differential control of Helios(+/−) Treg development by monocyte subsets through disparate inflammatory cytokines
Foxp3(+) regulatory T cells (Tregs) play a pivotal role in control of autoimmunity and pathological immune responses. Helios, the Ikarus family transcription factor, binds to the Foxp3 promoter, stabilizing its expression, and is expressed in 70% of peripheral Tregs of healthy individuals. This freq...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Hematology
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3612859/ https://ncbi.nlm.nih.gov/pubmed/23365462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-469122 |
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