Predicted metabolic drug clearance with increasing adult age

AIM: To determine the effect of increasing adult age on predicted metabolic drug clearance. METHOD: Predicted metabolic drug clearances (CL(PT)) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®. Sim...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Polasek, Thomas M, Patel, Farhaan, Jensen, Berit P, Sorich, Michael J, Wiese, Michael D, Doogue, Matthew P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2013
Soggetti:
Pharmacokinetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612720/
https://ncbi.nlm.nih.gov/pubmed/22924488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04446.x
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi