Predicted metabolic drug clearance with increasing adult age

AIM: To determine the effect of increasing adult age on predicted metabolic drug clearance. METHOD: Predicted metabolic drug clearances (CL(PT)) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®. Sim...

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Hlavní autoři: Polasek, Thomas M, Patel, Farhaan, Jensen, Berit P, Sorich, Michael J, Wiese, Michael D, Doogue, Matthew P
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2013
Témata:
Pharmacokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612720/
https://ncbi.nlm.nih.gov/pubmed/22924488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04446.x
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