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Influence of adult age on the total and free clearance and protein binding of (R)- and (S)-warfarin
AIMS: To test the hypothesis that the clearance (CL) of warfarin, a very highly protein bound drug with capacity-limited metabolism, decreases with age. METHODS: In a clinical study, a steady-state blood sample was taken from 72 patients (18–89 years) on routine treatment with warfarin. Concentratio...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Science Inc
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3495144/ https://ncbi.nlm.nih.gov/pubmed/22380743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04259.x |
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