Influence of adult age on the total and free clearance and protein binding of (R)- and (S)-warfarin

AIMS: To test the hypothesis that the clearance (CL) of warfarin, a very highly protein bound drug with capacity-limited metabolism, decreases with age. METHODS: In a clinical study, a steady-state blood sample was taken from 72 patients (18–89 years) on routine treatment with warfarin. Concentratio...

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Detaylı Bibliyografya
Asıl Yazarlar: Jensen, Berit Packert, Chin, Paul Ken Leong, Roberts, Rebecca Lee, Begg, Evan James
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2012
Konular:
Pharmacokinetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495144/
https://ncbi.nlm.nih.gov/pubmed/22380743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04259.x
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