Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure

Hereditary spastic paraplegias are a clinically and genetically heterogeneous group of gait disorders. Their pathological hallmark is a length-dependent distal axonopathy of nerve fibers in the corticospinal tract. Involvement of other neurons can cause additional neurological symptoms, which define...

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Bibliographische Detailangaben
Hauptverfasser: Beetz, Christian, Johnson, Adam, Schuh, Amber L., Thakur, Seema, Varga, Rita-Eva, Fothergill, Thomas, Hertel, Nicole, Bomba-Warczak, Ewa, Thiele, Holger, Nürnberg, Gudrun, Altmüller, Janine, Saxena, Renu, Chapman, Edwin R., Dent, Erik W., Nürnberg, Peter, Audhya, Anjon
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612678/
https://ncbi.nlm.nih.gov/pubmed/23479643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217197110
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