Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation

Length-dependent axonopathy of the corticospinal tract causes lower limb spasticity and is characteristic of several neurological disorders, including hereditary spastic paraplegia (HSP) and amyotrophic lateral sclerosis. Mutations in Trk-fused gene (TFG) have been implicated in both diseases, but t...

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Publicado no:Cell Rep
Main Authors: Slosarek, Erin L., Schuh, Amber L., Pustova, Iryna, Johnson, Adam, Bird, Jennifer, Johnson, Matthew, Frankel, E.B., Bhattacharya, Nilakshee, Hanna, Michael G., Burke, Jordan E., Ruhl, David A., Quinney, Kyle, Block, Samuel, Peotter, Jennifer L., Chapman, Edwin R, Sheets, Michael D., Butcher, Samuel E., Stagg, Scott M., Audhya, Anjon
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152936/
https://ncbi.nlm.nih.gov/pubmed/30157421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.081
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