Retrovirus-mediated transfer of an adenovirus gene encoding an integral membrane protein is sufficient to down regulate the receptor for epidermal growth factor.

Eitemau Tebyg

• Evidence for intracellular down-regulation of the epidermal growth factor (EGF) receptor during adenovirus infection by an EGF-independent mechanism.
  gan: Hoffman, P, et al.
  Cyhoeddwyd: (1992)
• E3-13.7 Integral Membrane Proteins Encoded by Human Adenoviruses Alter Epidermal Growth Factor Receptor Trafficking by Interacting Directly with Receptors in Early Endosomes
  gan: Crooks, Denise, et al.
  Cyhoeddwyd: (2000)
• The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus form a complex and function together to down-regulate the epidermal growth factor receptor.
  gan: Tollefson, A E, et al.
  Cyhoeddwyd: (1991)
• The adenovirus E3 14.5-kilodalton protein, which is required for down-regulation of the epidermal growth factor receptor and prevention of tumor necrosis factor cytolysis, is an integral membrane protein oriented with its C terminus in the cytoplasm.
  gan: Krajcsi, P, et al.
  Cyhoeddwyd: (1992)
• Adenovirus E3 protein causes constitutively internalized epidermal growth factor receptors to accumulate in a prelysosomal compartment, resulting in enhanced degradation.
  gan: Hoffman, P, et al.
  Cyhoeddwyd: (1994)