Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis

Cancer metastasis and immune suppression are critical issues in cancer therapy. Here, we show that a β-galactoside–binding lectin [galectin-3 (gal3)] that recognizes the Thomsen-Friedenreich disaccharide (TFD, Galβ1,3GalNAc) present on the surface of most cancer cells is involved in promoting angiog...

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Detalhes bibliográficos
Main Authors: Guha, Prasun, Kaptan, Engin, Bandyopadhyaya, Gargi, Kaczanowska, Sabina, Davila, Eduardo, Thompson, Keyata, Martin, Stuart S., Kalvakolanu, Dhananjaya V., Vasta, Gerardo R., Ahmed, Hafiz
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612646/
https://ncbi.nlm.nih.gov/pubmed/23479624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202653110
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