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Pure hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid
The role of pro-inflammatory cytokine production in the pathogenesis of malaria is well established, but the identification of the parasite products that initiate inflammation is not complete. Hemozoin is a crystalline metabolite of hemoglobin digestion that is released during malaria infection. In...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3612522/ https://ncbi.nlm.nih.gov/pubmed/19783673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0713552 |
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