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Immune surveillance for ERAAP dysfunction
The ER aminopeptidase associated with antigen processing, ERAAP (or ERAP1), is essential for trimming peptides that are presented by MHC class I molecules. ERAP1 is inhibited by human cytomegalovirus, and ERAP1 polymorphisms are associated with autoimmune diseases. How the immune system detects ERAA...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3612377/ https://ncbi.nlm.nih.gov/pubmed/23433779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2012.10.006 |
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