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Immune surveillance for ERAAP dysfunction

The ER aminopeptidase associated with antigen processing, ERAAP (or ERAP1), is essential for trimming peptides that are presented by MHC class I molecules. ERAP1 is inhibited by human cytomegalovirus, and ERAP1 polymorphisms are associated with autoimmune diseases. How the immune system detects ERAA...

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Bibliografiske detaljer
Main Authors: Nagarajan, Niranjana A., Shastri, Nilabh
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612377/
https://ncbi.nlm.nih.gov/pubmed/23433779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2012.10.006
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