Leucine Facilitates Insulin Signaling through a Gα(i) Protein-dependent Signaling Pathway in Hepatocytes

In this study, we addressed the direct effect of leucine on insulin signaling. In investigating the associated mechanisms, we found that leucine itself does not activate the classical Akt- or ERK1/2 MAP kinase-dependent signaling pathways but can facilitate the insulin-induced phosphorylations of Ak...

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Detalhes bibliográficos
Principais autores: Yang, Xuefeng, Mei, Shuang, Wang, Xiaolei, Li, Xiang, Liu, Rui, Ma, Yan, Hao, Liping, Yao, Ping, Liu, Liegang, Sun, Xiufa, Gu, Haihua, Liu, Zhenqi, Cao, Wenhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3611002/
https://ncbi.nlm.nih.gov/pubmed/23404499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.409409
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