Leucine Facilitates Insulin Signaling through a Gα(i) Protein-dependent Signaling Pathway in Hepatocytes

In this study, we addressed the direct effect of leucine on insulin signaling. In investigating the associated mechanisms, we found that leucine itself does not activate the classical Akt- or ERK1/2 MAP kinase-dependent signaling pathways but can facilitate the insulin-induced phosphorylations of Ak...

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Autori principali: Yang, Xuefeng, Mei, Shuang, Wang, Xiaolei, Li, Xiang, Liu, Rui, Ma, Yan, Hao, Liping, Yao, Ping, Liu, Liegang, Sun, Xiufa, Gu, Haihua, Liu, Zhenqi, Cao, Wenhong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3611002/
https://ncbi.nlm.nih.gov/pubmed/23404499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.409409
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