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Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia

Microglia are resident brain macrophages, which can cause neuronal loss when activated in infectious, ischemic, traumatic, and neurodegenerative diseases. Caspase-8 has both prodeath and prosurvival roles, mediating apoptosis and/or preventing RIPK1-mediated necroptosis depending on cell type and st...

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Detalhes bibliográficos
Main Authors: Fricker, Michael, Vilalta, Anna, Tolkovsky, Aviva M., Brown, Guy C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610987/
https://ncbi.nlm.nih.gov/pubmed/23386613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.427880
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