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Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

Tau protein forms insoluble filamentous inclusions that are closely associated with nerve cell death in many neurodegenerative diseases. How neurons die in these tauopathies is unclear. We report that living neurons with tau inclusions from P301S-tau mice expose abnormally high amounts of phosphatid...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Brelstaff, Jack, Tolkovsky, Aviva M., Ghetti, Bernardino, Goedert, Michel, Spillantini, Maria Grazia
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161320/
https://ncbi.nlm.nih.gov/pubmed/30134156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.072
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