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Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

Tau protein forms insoluble filamentous inclusions that are closely associated with nerve cell death in many neurodegenerative diseases. How neurons die in these tauopathies is unclear. We report that living neurons with tau inclusions from P301S-tau mice expose abnormally high amounts of phosphatid...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Brelstaff, Jack, Tolkovsky, Aviva M., Ghetti, Bernardino, Goedert, Michel, Spillantini, Maria Grazia
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161320/
https://ncbi.nlm.nih.gov/pubmed/30134156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.072
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