The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice

Identification of fluorescent dyes that label the filamentous protein aggregates characteristic of neurodegenerative disease, such as β-amyloid and tau in Alzheimer's disease, in a live cell culture system has previously been a major hurdle. Here we show that pentameric formyl thiophene acetic...

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Bibliographic Details
Published in:Front Neurosci
Main Authors: Brelstaff, Jack, Ossola, Bernardino, Neher, Jonas J., Klingstedt, Therése, Nilsson, K. Peter R., Goedert, Michel, Spillantini, Maria Grazia, Tolkovsky, Aviva M.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Psychiatry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448042/
https://ncbi.nlm.nih.gov/pubmed/26074756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2015.00184
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