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The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice

Identification of fluorescent dyes that label the filamentous protein aggregates characteristic of neurodegenerative disease, such as β-amyloid and tau in Alzheimer's disease, in a live cell culture system has previously been a major hurdle. Here we show that pentameric formyl thiophene acetic...

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Dettagli Bibliografici
Pubblicato in:Front Neurosci
Autori principali: Brelstaff, Jack, Ossola, Bernardino, Neher, Jonas J., Klingstedt, Therése, Nilsson, K. Peter R., Goedert, Michel, Spillantini, Maria Grazia, Tolkovsky, Aviva M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448042/
https://ncbi.nlm.nih.gov/pubmed/26074756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2015.00184
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