Full and Partial Agonists of Thromboxane Prostanoid Receptor Unveil Fine Tuning of Receptor Superactive Conformation and G Protein Activation

The intrahelical salt bridge between E/D(3.49) and R(3.50) within the E/DRY motif on helix 3 (H3) and the interhelical hydrogen bonding between the E/DRY and residues on H6 are thought to be critical in stabilizing the class A G protein-coupled receptors in their inactive state. Removal of these int...

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Bibliographic Details
Main Authors: Capra, Valérie, Busnelli, Marta, Perenna, Alessandro, Ambrosio, Manuela, Accomazzo, Maria Rosa, Galés, Celine, Chini, Bice, Rovati, G. Enrico
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610872/
https://ncbi.nlm.nih.gov/pubmed/23555978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060475
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