A single amino acid change in CUP2 alters its mode of DNA binding.

CUP2 is a copper-dependent transcriptional activator of the yeast CUP1 metallothionein gene. In the presence of Cu+ and Ag+) ions its DNA-binding domain is thought to fold as a cysteine-coordinated Cu cluster which recognizes the palindromic CUP1 upstream activation sequence (UASc). Using mobility s...

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Bibliographic Details
Main Authors: Buchman, C, Skroch, P, Dixon, W, Tullius, T D, Karin, M
Format: Artigo
Language:Inglês
Published: 1990
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC361081/
https://ncbi.nlm.nih.gov/pubmed/2167439
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