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Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells

Fractionated radiotherapy (RT) is widely used in cancer treatment, because it preserves normal tissues. However, repopulation of radioresistant tumors during fractionated RT limits the efficacy of RT. We recently demonstrated that a moderate level of long-term fractionated radiation confers acquired...

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Detalhes bibliográficos
Main Authors: Shimura, Tsutomu, Ochiai, Yasushi, Noma, Naoto, Oikawa, Toshiyuki, Sano, Yui, Fukumoto, Manabu
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610725/
https://ncbi.nlm.nih.gov/pubmed/23388457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23719
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