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Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells

Fractionated radiotherapy (RT) is widely used in cancer treatment, because it preserves normal tissues. However, repopulation of radioresistant tumors during fractionated RT limits the efficacy of RT. We recently demonstrated that a moderate level of long-term fractionated radiation confers acquired...

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Bibliographische Detailangaben
Hauptverfasser: Shimura, Tsutomu, Ochiai, Yasushi, Noma, Naoto, Oikawa, Toshiyuki, Sano, Yui, Fukumoto, Manabu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610725/
https://ncbi.nlm.nih.gov/pubmed/23388457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23719
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