DNA Ligases I and III Cooperate in Alternative Non-Homologous End-Joining in Vertebrates

Biochemical and genetic studies suggest that vertebrates remove double-strand breaks (DSBs) from their genomes predominantly by two non-homologous end joining (NHEJ) pathways. While canonical NHEJ depends on the well characterized activities of DNA-dependent protein kinase (DNA-PK) and LIG4/XRCC4/XL...

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Main Authors: Paul, Katja, Wang, Minli, Mladenov, Emil, Bencsik-Theilen, Alena, Bednar, Theresa, Wu, Wenqi, Arakawa, Hiroshi, Iliakis, George
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610672/
https://ncbi.nlm.nih.gov/pubmed/23555685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059505
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