Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein

The interferon-induced dynamin-like MxA GTPase restricts the replication of influenza A viruses. We identified adaptive mutations in the nucleoprotein (NP) of pandemic strains A/Brevig Mission/1/1918 (1918) and A/Hamburg/4/2009 (pH1N1) that confer MxA resistance. These resistance-associated amino ac...

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Bibliographic Details
Main Authors: Mänz, Benjamin, Dornfeld, Dominik, Götz, Veronika, Zell, Roland, Zimmermann, Petra, Haller, Otto, Kochs, Georg, Schwemmle, Martin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610643/
https://ncbi.nlm.nih.gov/pubmed/23555271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003279
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