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Methamphetamine oxidatively damages parkin and decreases the activity of 26S proteasome in vivo
Methamphetamine (METH) is toxic to dopaminergic (DAergic) terminals in animals and humans. An early event in METH neurotoxicity is oxidative stress followed by damage to proteins and lipids. The removal of damaged proteins is accomplished by the ubiquitin-proteasome system (UPS) and the impairment o...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3610410/ https://ncbi.nlm.nih.gov/pubmed/21166679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.07147.x |
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