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The role of Cysteine 6.47 in class A GPCRs
BACKGROUND: The CWxP motif of transmembrane helix 6 (x: any residue) is highly conserved in class A GPCRs. Within this motif, W6.48 is a big star in the theory of the global “toggle switch” because of its key role in the activation mechanism of GPCRs upon ligand binding. With all footlights focused...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3610275/ https://ncbi.nlm.nih.gov/pubmed/23497259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-13-3 |
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