EphA5-EphrinA5 Interactions Within the Ventromedial Hypothalamus Influence Counterregulatory Hormone Release and Local Glutamine/Glutamate Balance During Hypoglycemia

Activation of β-cell EphA5 receptors by its ligand ephrinA5 from adjacent β-cells has been reported to decrease insulin secretion during hypoglycemia. Given the similarities between islet and ventromedial hypothalamus (VMH) glucose sensing, we tested the hypothesis that the EphA5/ephrinA5 system mig...

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Detalhes bibliográficos
Main Authors: Szepietowska, Barbara, Zhu, Wanling, Czyzyk, Jan, Eid, Tore, Sherwin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609598/
https://ncbi.nlm.nih.gov/pubmed/23274893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0982
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